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Designer modulators

Nature Methods volume 4, page 988 (2007)Cite this article

Abstract

Through convergent engineering researchers modified both the protein surface and a small molecule, creating a specific interaction to manipulate protein activity.

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Figure 1: Convergent engineering.

References

  1. Vincent, F. et al. Engineering unnatural nucleotide specificity to probe G protein signaling. Chem. Biol. 14, 1007–1018 (2007).

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Authors
  1. Katherine Stevens
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Stevens, K. Designer modulators. Nat Methods 4, 988 (2007). https://doi.org/10.1038/nmeth1207-988

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  • DOI: https://doi.org/10.1038/nmeth1207-988

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