Abstract
Several methods are available for the study of antibody-antigen complexes. Present techniques, however, rely on indirect measurements of antibody binding, and do not reveal any information on what the antibody-antigen complex and possible associated proteins look like. Protein Tomography™ makes it possible, for the first time, to see antibodies free or bound to their target, both in solution and in tissue.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout
References
Sandin, S., Ofverstedt, L.G., Wikstrom, A.C., Wrange, O. & Skoglund, U. Structure and flexibility of individual immunoglobulin G molecules in solution. Structure (Camb.) 12, 409–415 (2004).
Author information
Authors and Affiliations
Additional information
Disclaimer
This article was submitted to Nature Methods by a commercial organization and has not been peer reviewed. Nature Methods takes no responsibility for the accuracy or otherwise of the information provided.
Rights and permissions
About this article
Cite this article
Gadnell, M. Protein Tomography™—answering prevailing scientific questions in therapeutic-antibody research and development. Nat Methods 3, I–II (2006). https://doi.org/10.1038/nmeth966
Published:
Issue date:
DOI: https://doi.org/10.1038/nmeth966
