Abstract
Although genetically modified mice have huge potential for the analysis of gene function, the creation of such mice via homologous recombination in embryonic stem cells (ESCs) is a tedious process. A combination of the CytoClone™ system from Evotec Technologies for cell selection with the ArteMice™ platform from Artemis Pharmaceuticals for rapid generation of genetically modified mouse models from engineered ESCs offers a fast and gentle way to isolate such cells.
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References
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Eggan, K. et al. Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nat. Biotechnol. 20, 455–459 (2002).
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Kauselmann, G., Kern, H., Klein-Vehne, A. et al. Automated sorting of genetically engineered embryonic stem cells for generation of mouse models. Nat Methods 4, v–vi (2007). https://doi.org/10.1038/nmeth994
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DOI: https://doi.org/10.1038/nmeth994
