Figure 5: Abundances of exocrine pancreatic proteins in the faecal samples of individuals with T1DM and correlating transcripts for metabolic enzymes.
From: Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes
a,b, Relative protein abundances of human AMY2A (a) and AMY2B (b). Boxes span the first to third quartiles, the central thick bars represent the medians, and whiskers extend to 1.5 times the interquartile ranges. All data points are represented. Boxes to the left of the dashed lines represent healthy individuals and boxes to the right represent individuals with T1DM belonging to the respective families. c, Correlation of microbial transcript abundances of KOs from a reconstructed metabolic network with AMY2 protein abundances. Heatmaps of normalized microbial transcript abundances of KOs are scaled as indicated in the colour key. Pathways with at least three enzymes and significant enrichment are highlighted with orange (nicotinate and nicotinamide metabolism) and blue (glycolysis and gluconeogenesis) lines (FDR-adjusted P < 0.05). At the top of the heatmap, higher relative abundances of AMY2 are indicated in darker grey tones, and individuals with T1DM are indicated by a black box. Individual colours follow the same colour scheme used throughout the figures (Fig. 1a; see Supplementary Table 1a for the total number of samples per individual).
