Supplementary Figure 4: Behaviors of heterotopic progenitor cells in TAG-1–KD cerebral walls
From: TAG-1–assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding
a) Different classes of neocortical neurons are sequentially produced in TAG-1–KD cerebral walls displaying a mosaic-like abnormal histogenetic pattern. Note that a certain fraction of Cux1+ neurons were found more basally than in the control, probably reflecting heterotopic production of these neurons, as suggested by in vitro analysis (Fig. 8g,h). b,c) Expression of ZO1 (b) and N-cadherin (c) at the apical surface of a TAG-1–deficient E13 cerebral wall. Aberrant expression of these “apical markers” was seen in portions where heterotopic progenitor cells formed aggregates.
