Supplementary Figure 2: Progenitor cell organization in the macaque MGE.
From: Non-epithelial stem cells and cortical interneuron production in the human ganglionic eminences
Cellular components and cytoarchitecture of macaque MGE at gestational day 65 (equivalent to human PCW10), sagittal views. Magnified regions 1 and 2 show the three MGE progenitor cell compartments. The ventricular zone (VZ) consists mainly of undifferentiated progenitor cells (radial glia) that express SOX2 and OLIG2. The inner subventricular zone (ISVZ) is enriched with neuronally committed progenitor cells that express ASCL1 and DLX2. The outer SVZ (OSVZ) is a heterogeneous mixture of both undifferentiated and lineage-committed progenitor cells, together with newborn neurons that have downregulated SOX2, OLIG2, ASCL1 and Ki67 but continue to express DLX2. Early formation of type II clusters is observed in the OSVZ, featured in magnified regions 3 and 4. D, V, R, C: dorsal, ventral, rostral, caudal.
