Supplementary Figure 4: Optogenetic stimulation of Purkinje cells elicits eye movements
From: Cerebellar Purkinje cell activity drives motor learning
(a) Schematic of the VOR circuit. The inhibitory Purkinje cells (PC) are only two synapses from the oculomotor neurons (MN). GC, granule cell; PF, parallel fiber; VN, vestibular nucleus. (b) Optogenetic Purkinje cell stimulation elicited eye movement responses at short latencies. When brief (5 ms) light pulses were delivered at a relatively low frequency (20 Hz), the eye movement elicited by each pulse could be resolved, illustrating the effectiveness of Purkinje cell activity to affect online motor performance.
