Supplementary Figure 4: Distribution of methylation difference between multiple sclerosis and controls shows most changes to be subtle.
From: Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains
(a) Density plots based on β-values obtained from 461,272 autosomal CpGs show a bimodal distribution of DNA methylation levels in the genome (black). Density plots of CpGs within hypomethylated (red) and hypermethylated (green) DMRs show a significantly different distribution (p<10–10, Kolmogorov-Smirnov test), with an excess of intermediate methylation levels. (b) Difference taken as the β-value average of MS minus the β-value average of controls. Distribution of methylation level difference for each CpG identified in differentially methylated regions are divided into three categories: <0.05, 0.05–0.10, or >0.10.
