Supplementary Figure 7: Impact of patient-derived BTICs on survival of mice; AmpB treatment reduces tumor growth and prevents the weight loss that occurs in mice with intracranial tumors.
From: Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells
(a) Survival curve of mice implanted intracranially with 100 (e2) to 10,000 (e5) 25EF BTICs, n=5 for all groups, with log-rank analysis. (b) MRI image shows a large intracranial tumor (arrow) 7 weeks post-implantation in a control mouse with 48EF cells which was significantly reduced with AmpB treatment; the quantification of tumor area by MRI is shown in (c) (unpaired t-test, n=4 for all groups). (d) Absolute body weight (left) or weight displayed as change from that at start of experiment (right), n=10 mice each group. Error bars, s.d.
