Supplementary Figure 2: Relative surface expression, measured by a fluorescence-activated cell sorter, does not correlate with relative potency (a) (Spearman rho=-0.01, n=38, p=0.95) or relative efficacy (b) (Spearman rho=0.16, n=38, p=0.33).
From: The missense of smell: functional variability in the human odorant receptor repertoire
For each variant we compared the change in mean surface expression (PE fluorescence intensity) to the change in the receptor potency (EC50 from the best-fit sigmoidal model) or receptor efficacy (top-bottom from the best-fit sigmoidal model) relative to the most common functional variant.
