Supplementary Figure 7: Amyloid fibrils induced significant change in mSin3A but not HDAC1 expression in the hippocampal CA1 area.
From: Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency
(a) Significant increase in protein levels of mSin3A (n = 6 and 9 rats per group, t = 5.6, P<0.0001), but not HDAC1 (n = 9 rats in each group, t = 0.9, P = 0.360), in the hippocampal CA1 of amyloid-injected rats. (b) Significant increase in binding of mSin3A (n = 9 rats per group, t = 4.1, P = 0.0008), but not HDAC1 (n = 6 rats per group, t = 0.4, P = 0.718), with MeCP2 in the hippocampal CA1 of amyloid-injected rats. Significant increase in binding of mSin3A (d, n = 6 rats per group, t = 2.7, P = 0.024), but not HDAC1 (c, n = 6 rats per group, t = 0.3, P = 0.772), in Nlgn1 promoter region in the hippocampal CA1 of amyloid-injected rats. Data represent mean ± s.e.m. *, P<0.05, **, P<0.01. Full length blots are presented in supplementary figure 11.
