Supplementary Figure 4: Circadian clock entrainment is necessary for aftereffects.
From: Circadian behavior is light-reprogrammed by plastic DNA methylation
Wheel running behavior of mice before, during and after entrainment to LD 11:11 or 10:10. Representative actograms of 4-week-old mice (a, b) exposed to DD for 7 days and then entrained to LD 11:11 or 10:10 LD cycles for 3 weeks. Whereas 11:11 mice could entrain to the assigned photoperiod, 10:10 mice could not. After entrainment, mice were released into DD for 7 days. (c) Average FRP before and after entrainment (n = 5 mice per group, t-test LD 11:11 ** p = 0.0010 and LD 10:10 p = 0.6062, mean ±s.e.m. shown).
