Supplementary Figure 5: eCB-LTD is not blocked by opioid receptor antagonists, and OP-LTD is not blocked by a CB1 antagonist.
From: Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
(a) Pre-application of the CB1 receptor antagonist, AM251 (3 μM), did not alter mOP-LTD induced by DAMGO (0.3 μM to 1 μM, 5 min; at 30 min:P=0.9836, t(8)=0.02127, n=5 each). (b) Pre-application of AM251 (3 μM) did not alter dOP-LTD induced by DPDPE (0.3 μM to 1 μM, 5 min; at 30 min: P=0.5996; t(9)=0.5441, n=5 control, n=6 AM251). (c) Pre-application of the opioid receptor antagonist, naloxone (2 μM), did not alter eCB-LTD induced by HFS paired with postsynaptic depolarization (at 30 min: P=0.6162, t(10)=0.5173, n=6 each). Data analyzed with unpaired Student's t-test.
