Supplementary Figure 1: Field recordings reveal OP-LTD of net striatal output.
From: Opioids induce dissociable forms of long-term depression of excitatory inputs to the dorsal striatum
(a) DAMGO (1 μM, 5 min) induced mOP-LTD of population spike amplitude in field recordings of the DLS (vs. control: P=0.0219, t(12)=2.631, n=14). (b) DPDPE (1 μM, 5 min) induced dOP-LTD of population spike amplitude in field recordings of the DLS (vs. control: P=0.0047, t(14)=3.360, n=16). (c) U69,593 (1 μM, 5 min) induced kOP-LTD of population spike amplitude in field recordings of the DLS (vs. control: P=0.0317, t(14)=2.386, n=16). Representative traces are the average of the first 5 min (first of each pair) and the final 5 min (second of each pair) of recording. Scale bars: 0.2 mV, 2 ms. Data analyzed with unpaired Student's t-test.
