Supplementary Figure 10: Correlation analysis of mEPSC frequency.
From: Linker mutations reveal the complexity of synaptotagmin 1 action during synaptic transmission
(a) Lack of correlation between the ability of the syt linker mutants to regulate evoked versus spontaneous release. Data for mEPSCs and eEPSCs are from Fig. 6d and Fig. 2b, respectively. (b) Correlation plot of the ability of the syt linker mutants to suppress spontaneous release, and to bind t-SNAREs in the absence of Ca2+. Data for mEPSCs are from Fig. 6d and Ca2+-independent t-SNARE binding activity was obtained from Supplementary Fig. 4a. Plotted values represent the mean ± SEM. Equations and p-values for the linear regressions are listed in Supplementary Table 1.
