Supplementary Figure 9: Characterization of Q175 mice. | Nature Neuroscience

Supplementary Figure 9: Characterization of Q175 mice.

From: Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Supplementary Figure 9

Representative images show there no CP volume change in wild type mice and heterozygous Q175 mice by Nissl staining at 6-7 months. Bar graph in right summaries the striatal area between two groups. (B) Representative images show decrease of the striatal volume in heterozygous Q175 mice at 12 months compared with comparative wild type mice. Bar graph in right shows the significant decrease of striatal areas in heterozygous Q175 mice. (C) Summary of western blots of Kir4.1, glutamine synthetase (GS), GLT-1 and GFAP protein expression levels in striatums of wild type, heterozygous and homozygous Q175 mice at 6-7 months and 9-12 months. Statistical tests were done using un paired Student's t tests; p values are shown. n indicates the number of animals in each group.

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