Supplementary Figure 12: Controls for AAV2/5 Kir4.1-GFP. | Nature Neuroscience

Supplementary Figure 12: Controls for AAV2/5 Kir4.1-GFP.

From: Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

Supplementary Figure 12

a. Astrocyte current-voltage (IV) relations. AAV2/5 Kir4.1-GFP expression in R6/2 mice increases the slope of the astrocyte IV relations and restores them to WT levels. However, Kir4.1-GFP expression in WT astrocytes did not boost the IV relations higher than WT levels. b. Ba2+ sensitive currents under the conditions shown. c-e. Western blot analysis from R6/2 mice injected with AAV2/5 for Kir4.1-GFP or AAV2/5 tdTomato. The Western blot data are for GFP (c) total Kir4.1 (d) and Glt-1 (e). Statistical differences were assessed using un paired Student's t tests. P values are shown.

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