Supplementary Figure 8: Slow changes in dopamine release in the VMS following a cocaine infusion induced by an active nose-poke response.
From: Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
Increases in peak concentration of extracellular dopamine in the VMS measured during LgA cocaine self-administration sessions. Measurements were conducted over 90 seconds following an infusion of cocaine induced by a nose poke into the active hole (that occurred without additional operant responses within 90 seconds following this infusion) prior to escalation (pre-esc), after escalation (esc), and after escalation with L-DOPA treatment (L-DOPA). Average changes in such “tonic” dopamine concentration did not differ significantly from each other (ns, not significant; P >0.05). Data are mean+SEM.
