Supplementary Figure 4: Examples of phasic dopamine release in VMS and DLS associated with an individual nose poke (single trial) into the active port for animals with non-escalated, stable cocaine intake.
From: Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
a, Pseudocolor plots (top panel), dopamine traces (bottom panel), and cyclic voltammograms (inset in bottom panel) for representative current fluctuations recorded in VMS for the period 10 seconds before an operant response (dashed line), during the subsequent 20-second presentation of the CS (yellow box; includes cocaine infusion), and 10 seconds after the offset of the CS during the first (Left), second (Middle), and third (Right) weeks of LgA cocaine self-administration (first hour). b, Pseudocolor plots (top panel), dopamine traces (bottom panel), and cyclic voltammograms (inset in bottom panel) for representative current fluctuations recorded in DLS during the first (Left), second (Middle), and third (Right) weeks of LgA cocaine self-administration. The color plots show current changes across the applied voltages (Eapp; y-axis) over time (x-axis).
