Supplementary Figure 6: Accumulation of FTY720-P in various brain regions. | Nature Neuroscience

Supplementary Figure 6: Accumulation of FTY720-P in various brain regions.

From: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory

Supplementary Figure 6

SCID mice were treated daily with FTY720 as described in Fig. 5d. Blood was collected and brain regions were isolated and levels of FTY720 and FTY720-P were measured by LC-ESI-MS/MS. Note: Assuming brain is 75% water, the concentration of FTY720-P in hippocampus for example is ∼9 μM compared to 0.27 μM in blood.

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