Supplementary Figure 9: ALK5CA mice do not show any changes in total number of entries in the Y maze or the percentage of freezing under pre-tone and tone conditions in fear conditioning compared with genotype-matched control mice.
From: ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis
(a) Total number of entries in the Y maze was measured from 3-month-old male WT, tTA, ALK5Ctrl, and ALK5CA mice. n = 18 mice per group. (b) Fear conditioning assessed by the percentage of freezing was displayed by 3-month-old male WT, tTA, ALK5Ctrl, and ALK5CA mice before tone and when re-exposed 24 hours later to the tone. n = 11 mice per group. In (b), time × genotype interaction F(3,40) = 0.1782, P = 0.9106; time F(1,40) = 330.9, P < 0.0001; genotype F(3,40) = 0.1832, P = 0.9072. One-way ANOVA, Tukey's post-hoc test (a); Two-way repeated-measures ANOVA, Bonferroni's post-hoc test (b).
