Supplementary Figure 4: Neuropathology-associated elevation of ANK1 isoform 5-7-10.
From: Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease
Three qPCR assays with specificity to ANK1 isoforms i) 1-2-3-4, ii) 9, and iii) 5-7-10 were run on 36 EC samples in the London cohort from whom RNA was available (see Supplementary Table S2). We found a significant association (ANOVA P = 0.04) between the abundance of isoform 5-7-10 transcripts and AD-associated neuropathology. No significant differences in transcript levels were observed for the other two isoform-specific assays (data not shown). Source Data is provided in the Supplementary Figure Source Data file.
