Supplementary Figure 8: Generation of oligodendroglioma using IUE and PiggyBacs to target OL lineages with oncogenes | Nature Neuroscience

Supplementary Figure 8: Generation of oligodendroglioma using IUE and PiggyBacs to target OL lineages with oncogenes

From: Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes

Supplementary Figure 8

Brain from P14 mouse IUE at E16.5 with GLAST-PBase and MBP-GFPt2aRas (A). Arrow denotes region electroporated and dotted line denotes cross section analyzed in B; dotted line in B is midlne. H&E staining of tumors (C-D). Tumors demonstrate pathological hallmarks of oligodendrolglioma, including small monomorphic nuclei lacking processes, perineuronal satellitosis, and invasion into perivascular and subpial spaces. Dashed box in C is magnified area in D. Circle in D demonstrates typical perineuronal satellitosis. Olig2 staining in mouse oligodendroglioma (E-H). Co-expression of ectopic HA-NFIA with Ras-GFP expressing cells in astrocytoma-like tumors (H-J).

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