Supplementary Figure 4: Striatal responses to cerebellar stimulations are blocked by isoflurane-induced anesthesia.
From: Short latency cerebellar modulation of the basal ganglia
Previous work has demonstrated that striatal responses to cerebellar stimulation occur only with strong trains of cerebellar stimulation and at latencies between 50-350 ms. However, the recordings were made under anesthesia. To test whether anesthesia influences striatal responses to cerebellar stimulation, after obtaining reliable striatal responses to cerebellar stimulation in awake mice, the animals were anesthetized using isoflurane. In all cases examined (n=34, N=4) isoflurane-induced anesthesia reversibly abolished cerebellar-induced striatal responses. An example experiment is shown
