Supplementary Figure 8: Spontaneous firing in LA neurons was greater in rats exhibiting high (N = 6; Fig. 5) levels of fear generalization compared to those showing low (N = 8; Fig. 4) fear generalization after weak US conditioning.
From: Neuronal encoding of the switch from specific to generalized fear
Cumulative probability distribution of spontaneous firing rates of all recorded LA neurons (solid lines) and only those showing conditioning-induced increase in firing (dotted lines) from rats exhibiting low (grey, n = 131, N = 8) and high (black, n = 114, N = 6) fear generalization. A subset of all the recorded LA neurons exhibited tone-evoked increased spiking after weak-US conditioning from low (grey, n = 37/131) and high (black, n = 43/114) generalizing rats. The frequency of spontaneous firing in all the recorded neurons (k = 0.28; p < 0.001, Kolmogorov-Smirnov test), as well as the smaller subset of conditioned neurons (k = 0.33; p = 0.02, Kolmogorov-Smirnov test), are significantly greater in the rats exhibiting high fear generalization compared to those showing low fear generalization. Spontaneous firing rate is estimated over 100 s pre-tone period (10 s, 10 trials) during habituation session. ***p < 0.001; *p< 0.05.
