Supplementary Figure 7: Functional characterization of hES cell– and hiPS cell–derived LTMRs.
From: PIEZO2 is required for mechanotransduction in human stem cell–derived touch receptors
(a) Examples of mechanotransduction currents (bottom traces) elicited by mechanical stimuli of increasing magnitude (top traces) in hESC-derived LTMRs. Note that the mechanoreceptors do not show any response upon removal of the mechanical stimulus. (b) Representative example of an action potential (AP) recorded from human iPS-cell-derived neurons. Half peak duration (HPD) was 1.81±0.81ms (n=8), after-hyperpolarization (AHP) was 12.79±8,10ms (n=8) and time constant (Tau) was 7.96±1.75ms (n=6). (c) Example traces of mechanotransduction currents (bottom traces) elicited by mechanical stimuli of increasing magnitude (top traces) in human iPS-cell-derived LTMRs.
