Supplementary Figure 4: Concordance between differential expression in total RNA compared to cytosolic RNA.

Log2 fold changes comparing fetal to adult in 12 total RNA samples (discovery, six per age group) and 6 independent samples (3 per age group) with the cytosolic fraction separated from the nuclear mRNA for (A) all DERs and (B) only DERs overlapping annotated intronic regions. ρ = Spearman correlation, κ = directionality concordance.