Supplementary Figure 1: Hierarchical clustering of the implicated network.
From: Genotype to phenotype relationships in autism spectrum disorders
Average linkage hierarchical clustering was used to divide the implicated network into functional clusters. The inverses of the phenotypic network likelihood scores were used as the clustering metric. In this way, gene pairs strongly connected in the phenotypic network were considered to be closer in distance. Clusters were assigned the following functions using DAVID: green represents the neuronal signaling and cytoskeleton cluster, red represents the chromatin modification and regulation cluster, blue represents the channel activity cluster, and cyan represents the postsynaptic density cluster. Grey nodes represent genes that are not members of any considered cluster.
