Supplementary Figure 4: Trial outcome signals in hippocampal subregions
From: Frequency-specific hippocampal-prefrontal interactions during associative learning
(a) Mean selectivity (PEV) for trial outcome in hippocampal local-projection subregions (top; Dentate gyrus/CA3, n = 104 neurons) and output subregions (bottom; CA1/Subiculum, n = 93) neurons, plotted across learning stages (light-to-dark colors). Outcome signals are significantly stronger overall in the HPC output subregions (P ≤ 10−4, 2-way subregion × learning-stage ANOVA in outcome feedback epoch). (b) Mean bias (signed PEV) in HPC local-projection (top) and output subregion (bottom) neurons for correct (positive values) vs. incorrect (negative values) outcomes. With learning, there was a significant shift from stronger signals for incorrect to correct trials in HPC output subregions (P = 0.005, 2-sided permutation test on ITI epoch signals in early vs. late learning stages), but not local-projection subregions (P = 0.83, P = 0.04, interaction in 2-way subregion × learning-stage ANOVA).
