Supplementary Figure 6: Cyclin-dependent kinase 5 (CDK5) maintains brain tumor initiating cells (BTICs).
From: Mitochondrial control by DRP1 in brain tumor initiating cells
a. Effects of CDK5 knockdown with two independent lentiviral shRNA constructs on cell proliferation in two BTIC models. Data are represented as mean ± s.e.m. (387, p < 0.0001; 3565, p < 0.0001 by repeated measures ANOVA; n = 4). b. In vitro extreme limiting dilution assays (ELDA) to single cells demonstrate that knockdown of CDK5 in two BTIC models decreases the frequency of tumorsphere formation (387: p = 3.4 × 10−13; 3565: p = 2.2 × 10−8 by ANOVA). c. Proposed model of CDK5 regulation of DRP1 in BTICs.
