Supplementary Figure 2: Manipulation of Y1R, but not Y2R, in the BNST alters binge-like ethanol drinking during 2-cycle DID. | Nature Neuroscience

Supplementary Figure 2: Manipulation of Y1R, but not Y2R, in the BNST alters binge-like ethanol drinking during 2-cycle DID.

From: NPY signaling inhibits extended amygdala CRF neurons to suppress binge alcohol drinking

Supplementary Figure 2

(a−b) Mice that received bilateral intra-BNST infusions of LeuPro NPY prior to access to EtOH on Cycle 2 Day 4 consumed significantly less ethanol than CON mice (a; unpaired t-test: t(12) = 2.49, *p = 0.029; CON N = 8, LeuPro N = 6), but locomotor behavior in the OF was unaffected (b; p > 0.90; CON N = 6, LeuPro N = 9). (c−d) Bilateral intra-BNST infusions of BIIE 0246 did not alter binge ethanol consumption in 2-cycle DID (c; CON N = 3, BIIE N = 5) or locomotor behavior in the OF (d; CON N = 3, BIIE N = 4; unpaired t-tests: p’s > 0.70). All data are presented as mean ± SEM.

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