Supplementary Figure 4: Effect of overexpression of DISC1 or KIF5A-headless on dendritic localization of ITPR1 3สน UTR. | Nature Neuroscience

Supplementary Figure 4: Effect of overexpression of DISC1 or KIF5A-headless on dendritic localization of ITPR1 3สน UTR.

From: Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity

Supplementary Figure 4

Hippocampal neurons were transfected with Myc-GST, Myc-hDISC1-FL or Myc-KIF5A-headless (HL) and Venusโ€“ITPR1 3สน UTR plasmids at DIV 12. The transfected neurons were fixed at DIV 14 and immunostained with antibodies to Venus (green) and MAP2 (red). Blue bars indicate the distance between the soma and the farthest transported granules containing ITPR1 3สน UTR. Magnified images of the granules are shown in the boxed areas. Scale bars, 15 ฮผm.

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