Supplementary Figure 1: Gene profile from microglia in GF mice.
From: Host microbiota constantly control maturation and function of microglia in the CNS
mRNA expression values (number of reads) of genes from microglia in GF animals (white bars) or SPF mice (black bars). (a) Prototypical microglia genes are presented and compared to the non-microglia genes such as Gfap, Mog, Tubb3 and Rbfox3. (b) Epigenetic signature of microglia was examined by investigating genes (number of reads) related to histone acetylation, deacetylation, methylation and demethylation, respectively. Bars represent means ± s.e.m. with seven samples in each group. Significant differences were determined by an unpaired t test and marked with asterisks (*P < 0.05, **P < 0.01, ***P < 0.001). P values: Csf1r: 0.0001, Sfpi1: 0.0075, Hexb: 0.0060. Myst3: 0.0121, Hdac1: 0.0191, Sirt2: 0.0113, Sirt7: 0.0441, Mll3: 0.0489, Mll5: 0.0105, Setd1a: 0.0360, Setd7: 0.0134, Kdm4a: 0.0476, Kdm6b: 0.0005, Jarid2: <0.0001.
