Supplementary Figure 8: Effects of ILT- and PFC-vSTR activation with ChR2 on CSDS-induced behaviors.
From: Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
(a) Schematic, immunohistochemistry and in vitro validation of stimulation parameters of ILT neurons; scale bar = 200 μm. (b) Schematic, immunohistochemistry and, in vitro validation of stimulation parameters of PFC neurons circuit; scale bar = 200 μm (1 cell per trace). Time spent in corner zones in mice expressing either DIO-EYFP or ChR2 in (c) ILT-vSTR stimulation (EYFP/ChR2, n = 14/18 mice, 2-way ANOVA, *p = 0.045, F (1, 60) = 6.893 (interaction)) and (c) PFC-vSTR stimulation (EYFP/Chr2, n = 6 mice per group, 2-way ANOVA, p = 0.518, F (1, 20) = 0.4324 (interaction)) with blue light. Total distance traveled during social interaction in mice expressing either DIO-EYFP or ChR2 in (c) ILT-vSTR (EYFP/ChR2, n = 14/18 mice, 2-way ANOVA, p = 0.325, F (1, 60) = 0.9815 (interaction)) and (d) PFC-vSTR with blue light stimulation (n = 6 mice per group, 2-way ANOVA, p = 0.472, F (1, 20) = 0.5385 (interaction)).
