Supplementary Figure 10: Effects of high frequency PFC-vSTR ChR2 terminal stimulation on social defeat–induced behaviors.
From: Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
(a) Quantification of time spent in the interaction zone and social interaction ratio in previously susceptible animals with 100 Hz stimulation of ChR2-expressing PFC terminals during the SI test (EYFP/ChR2, n = 9/10 mice, two-ANOVA (Time spent) * p = 0.046, F (1, 34) = 4.294 (interaction), unpaired t-test (SI ratio) * p = 0.040, t = 2.214 df = 17). (b) Time spent in corner zones in mice expressing either EYFP or ChR2 and stimulation of PFC terminals during the SI test (EYFP/ChR2, n= 9/10 mice, 2-way ANOVA, p = 0.64, F (1, 34) = 0.2221 (interaction)). (c) Total distance traveled during social interaction in mice expressing either EYFP or ChR2 and stimulation of PFC terminals during the SI test (EYFP/ChR2, n = 9/10 mice, 2-way ANOVA, p = 0.813, F (1, 34) = 0.05669 (interaction)).
