Supplementary Figure 1: vSTR VGLUT2 levels correlate with susceptibility to social defeat stress
From: Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress
(a) Confocal images of VGLUT2 puncta in the vSTR of control, resilient and susceptible mice; scale bar = 10 μm. (b) Quantification of VGLUT2 puncta density (control/resilient/susceptible, n = 4/4/5 mice, one-way ANOVA, * p = 0.020, F (2,10) = 5.826). (c) Linear regression analysis revealing a significant correlation of VGLUT2 puncta density with social interaction ratio (r2 = 0.519, p = 0.005; curved lines represent the 95% confidence interval). (d) Confocal images of VGLUT1 puncta in the vSTR of control, resilient and susceptible mice; scale bar = 10 μm. (e) Quantification of VGLUT1 puncta density (control/resilient/susceptible, n = 4/3/5 mice, one-way ANOVA, p = 0.533, F (2,9) = 0.7205). (f) Linear regression analysis revealing no correlation of VGLUT1 puncta density to social interaction ratio (r2 = 0.005, p = 0.303; curved lines represent the 95% confidence interval). Confocal image of VGLUT1 puncta (red) and EYFP containing terminals (green) in the vSTR from the (g) ILT and (i) PFC; scale bar = 10 μm. Colocalization mask is shown to the right of each image. Confocal image of VGLUT2 puncta (red) and EYFP containing terminals (green) in the vSTR from the (h) ILT and (j) PFC; scale bar = 10 μm.
