Supplementary Figure 4: Representative traces of neurexin rescue experiments. | Nature Neuroscience

Supplementary Figure 4: Representative traces of neurexin rescue experiments.

From: Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses

Supplementary Figure 4

a & b. Nrxn3α/β cKO neurons were co-infected with inactive (control) or active (cre) cre-recombinase at DIV 4 and with a virus that expressed (a) an endogenously expressed soluble isoform of Nrxn3SS4– (solNrxn3βSS–-) that results from alternative splicing in splice-site 5 and (b) the extracellular domain of neurexin-1βSS4– was fused to the transmembrane and intracellular domains of PDGFR (pDisNrxn1βSS4-). This construct permits trans-synaptic signaling while inhibiting intracellular signaling.

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