Supplementary Figure 10: Quantitative sex differences in baseline mechanical sensitivity (a) and SNI- and CFA-induced mechanical allodynia (b–e) in various experiments.
From: Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Bars in a represent mean ± SEM baseline von Frey thresholds of various mouse populations by sex. Bars in b,c represent mean ± SEM mechanical allodynia in CD-1 mice measured at 7 days post-SNI surgery (b) or 3 days post-CFA injection (c) in various drug conditions or mouse populations by sex. Bars in d,e represent mean ± SEM mechanical allodynia measured at 7 days post-SNI surgery or 3 days post-CFA injection in CD-1 (wildtype) and nude mice (d) and C57BL/6 (wildtype) and Rag1−/− mice (e). *p<0.05, **p<0.01, ***p<0.001 compared to other sex within-genotype or condition by (uncorrected) t-test. The slightly but significantly increased neuropathic allodynia of female CD-1 mice (see graphs b,d) has not been observed previously, but is well-documented (Coyle et al., Neurosci. Lett. 1995; Dominguez et al., Eur. J. Pain, 2012; Dina et al., Neuroscience, 2007; LaCroix-Fralish et al., Neuroscience 2006; LaCroix-Fralish et al., Pain, 2005; Tall et al., Pharmacol. Biochem. Behav., 2001), although strain-dependent (DeLeo & Rutkowski, Neurosci. Lett., 2000), in the rat.
