Supplementary Figure 11: Female nude mice “switch” to a microglial-dependent system in the mediation of CFA allodynia.
From: Different immune cells mediate mechanical pain hypersensitivity in male and female mice
Graph shows reversal of mechanical allodynia 3 days after CFA by i.t. administered glial inhibitors minocycline (MCL), fluorocitrate (FC) and propentofylline (PPF) in male but not female CD-1 mice, but in immunocompromised nude mice of both sexes. Bars represent mean ± SEM percentage of maximum reversal of allodynia (% anti-allodynia) (n=4–7 mice/sex/drug/genotype). ANOVAs showed significant genotype x sex interactions in all cases (MCL: F1,19 = 7.1, p=0.01; FC: F1,16 = 7.7, p=0.01; PPF: F1,22 = 4.2, p=0.05). **p<0.01, ***p<0.001 compared to same‑strain female mice by t‑test. p<0.01, p<0.001 compared to same-sex CD-1 mice by t‑test.
