Supplementary Figure 12: Female Rag1−/− mice “switch” to a microglial-dependent system in the mediation of SNI and CFA allodynia. | Nature Neuroscience

Supplementary Figure 12: Female Rag1−/− mice “switch” to a microglial-dependent system in the mediation of SNI and CFA allodynia.

From: Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Supplementary Figure 12

Graph shows reversal of mechanical allodynia after SNI or CFA by i.t. minocycline (MCL; 50 μg) in male but not female wildtype (+/+; C57BL/6) mice, but in immunocompromised Rag1−/− (-/-) mice of both sexes. Bars represent mean ± SEM percentage of maximum reversal of allodynia (% anti-allodynia) (n=6–8 mice/sex/genotype). ANOVAs revealed significant genotype x sex interactions in both cases (SNI: F1,20 = 9.5, p=0.006; CFA: F1,24 = 4.7, p=0.04). ***p<0.001 compared to same‑genotype female mice by t‑test. p<0.01, p<0.001 compared to same‑sex +/+ mice by t-test.

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