Supplementary Figure 4: Ret+/– mutant mice exhibit no significant alterations in the levels of DA, 5-HT or their metabolites in the olfactory bulb and expression levels of DAT and phospho-Thr53-DAT in the NAc and VTA.
From: Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking
a, The levels of DA, 5-HT and their metabolites were measured in the olfactory bulb of Ret+/- and wild-type mice. The olfactory bulb (OB) is one of brain regions enriched in dopaminergic neurons. unpaired two-tailed t-test. (n=5 mice per group). t(8) = 0.8544. P = 0.4177 for DA. b, Western blotting reveals that the levels of phosphor-Thr53-DAT expression are not significantly altered in the NAc and VTA between genotypes. b shows cropped blot images from their corresponding full-length blots presented in Supplementary Figure 12. c, Quantitative data of b. unpaired two-tailed t-test. (n = 3 mice per group). t(4) = 1.092, P = 0.3364 for NAc, t(4) = 1.672, P = 0.1698 for VTA. Error bars represent s.e.m.
