Supplementary Figure 2: Properties of robust brain expressed enhancers (rBEEs).
From: Coexpression networks identify brain region–specific enhancer RNAs in the human brain
(a) rBEE length distribution. (b) Boxplots of brain rBEE and gene expression levels based on normalized FANTOM5 CAGE data. (c) eRNA expression enrichment in the brain. Heatmaps display scaled rBEE expression values (z-scores) in brain samples relative to non-brain samples based on normalized FANTOM5 CAGE data. (top) Intronic rBEE. Gene names are listed in blue. Genes implicated in ASD are listed in red. (bottom) Intergenic rBEE. The color bars above the heatmaps display the brain region, color-coded as shown in the legend. The schematic display of brain regions was generated using the Brain Explorer software http://mouse.brain-map.org/static/brainexplorer. Brain region abbreviations shown between square brackets correspond to regions included in the dataset but not shown on the schematic representation of the brain. S1-S32: sample IDs as listed in Supplementary Table 9. Note that for the analysis of eRNA expression enrichment in the brain sample S33, a technical replicate, was excluded (see Online Methods).
