Supplementary Figure 4: D1-MSN input to the GP is weaker than that of the VP.
From: Coding the direct/indirect pathways by D1 and D2 receptors is not valid for accumbens projections
(a) Representative image of injection sites of Cre-dependent ChR2 into the dorsal striatum (D2-Cre mouse). Calibration bar – 500 μm. (b) In the GP almost all cells received dorsal striatum D2-MSN input while only 18% received D1-MSN input. (c) Representative eIPSCs recorded in a GP (a) or a VP (b) neuron and generated by 10 consecutive stimulations of D1-MSN input from the dorsal striatum or the NAc, respectively. Red trace represents the average of traces. (d) Failure rate (% trials showing failures) in GP neurons receiving D1-MSN input (6.0±6.0%) was similar to that in the VP (5.1±2.7%). (e) The amplitude of eIPSCs generated by D1-MSN input to the GP (85±48 pA) was lower than that measured in the VP (359±79 pA). (f) The latency for the eIPSC in the GP and the VP was the same (1.57±0.32 ms and 1.72±0.14 ms, respectively). Results are presented as mean±s.e.m. Error bars represent s.e.m.
