Supplementary Figure 4: Three-dimensional reconstructions of CA3 dendritic segments, thorny excrescences and postsynaptic densities in wild-type and Tc1 mice.
From: Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome
Dendritic segments and associated presynaptic giant boutons from (a) wild-type and (f) Tc1 mice. Boutons are shown separately in (b) for the wild-type example. Typical examples of thorny excrescences with their postsynaptic densities (PSD) shown in red from (c-d) wild-type and (g) Tc1 mice. 10 representative PSDs from (e) wild-type and (h) Tc1 mice, showing reduced PSD volume in Tc1 animals.
