Supplementary Figure 2: Normal synaptic function in the Schaffer collateral pathway in Tc1 mice.
From: Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome
(a) Pooled CA3-CA1 stimulus-response curves for recordings made in hippocampal slices from wild-type (WT) and Tc1 mice (mean ± SEM). Inset traces show overlaid example responses to 20, 40 and 80V stimulation for the two genotypes. (b) Pooled CA3-CA1 paired-pulse facilitation curves for paired stimuli delivered over inter-stimulus intervals from 25-400ms. Traces show example responses at each inter-stimulus interval. (c) Pooled data from CA3-CA1 LTP experiments in wild-type and Tc1 mice. Arrow denotes delivery of the conditioning stimulus (200ms, 100Hz repeated 3x at 1.5s intervals). Traces show example responses at times a and b. Scale bars: 5ms, 0.25mV.
