Supplementary Figure 8: Serum fluoxetine levels.
From: 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response
a) Serum fluoxetine levels in Control and POMC-Cre/fl1A mice. Control or POMC-Cre/fl1A mice were administered fluoxetine (18 mg/kg/day) starting at 8 weeks of age. Blood was collected three weeks after initiation of fluoxetine. There were no differences (Student’s t-test). n = 6 per group. b) Serum fluoxetine levels in Control and Nestin-CreER/fl1A mice. Control or Nestin-CreER/fl1A (8 wks) mice were administered fluoxetine (18 mg/kg/day) starting at 8 weeks of age. Nestin-CreER/fl1A (11 wks) mice were administered fluoxetine starting at 11 weeks of age. Blood was collected three weeks after initiation of fluoxetine. There were no differences (One-Way ANOVA). n = 6 per group. c) Serum fluoxetine levels in 1A KO and DG-1A+ mice. 1A KO or DG-1A+ mice were administered fluoxetine (18 mg/kg/day) starting at 8 weeks of age. Blood was collected three weeks after initiation of fluoxetine. There were no differences (Student’s t-test). n = 6 per group.
