Supplementary Figure 9: The interaction between mature DG GCs and young abGCs during the antidepressant response. | Nature Neuroscience

Supplementary Figure 9: The interaction between mature DG GCs and young abGCs during the antidepressant response.

From: 5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response

Supplementary Figure 9

SSRIs increase serotonin (5-HT) levels throughout the brain. Serotonin binds to somatodendritic 5HT1ARs (1A; red and blue cylinders) on mature DG GCs (blue cell) in order to trigger an antidepressant response. The mature DG GCs release growth factors such as BDNF and VEGF that enhance proliferation of neural progenitors and maturation of young abGCs (green cell). young abGCs may then modulate the mature DG GCs by acting on the local microcircuit. The resulting combined activity of the mature DG GCs and young abGCs defines the output of the dentate gyrus into a circuit that mediates the antidepressant response. The borders of the granule cell layer (GCL) with the molecular layer (ML) and Hilus are indicated with a dashed orange line.

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