Supplementary Figure 4: Internalization of APP in neuronal soma.
From: Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway
(a, b) Neurons were co-transfected with BBS-APP and various organelle markers, incubated with BTX-594, and internalized APP was evaluated in cell bodies by colocalization analyses (see ‘methods’). Colocalization of internalized BTX-594 with organelle markers was as follows: TfR (41.6 %), Rab5 (49.9), GalT (44.1), NPYss (31.2 %), and LAMP-1 (79.1 %). 10-18 neurons from two separate cultures were analyzed; * p < 0.05.
