Supplementary Figure 10: Scheme of GABAergic excitation and inhibition of AP firing.
From: Bidirectional GABAergic control of action potential firing in newborn hippocampal granule cells
(a) Presynaptic APs in glutamatergic fibers of the molecular layer (ML) generate EPSPs, which are too small to evoke APs in young granule cells. (b) Pairing of subthreshold PSPs in ML with a low number of active GABAergic synapses in the granule cell layer (GCL; 5-30% of GABAergic connections) will generate an axonal spike output. (c) Stronger GABAergic activity with more than 40% of synapses activated will effectively inhibit AP firing.
