Supplementary Figure 12: Descending pathways via which nutrient sensing in basal ganglia may command feeding motor programs.
From: Separate circuitries encode the hedonic and nutritional values of sugar
Separate dorsal (blue lines) and ventral (red lines) circuits may activate a common brainstem oral-motor central pattern generator (CPG) via segregated descending pathways. This model is consistent with the animal’s ability to persist licking an aversive solution whenever this solution is associated with energy gain. Connections ending as triangles represent excitatory/modulatory connections. Connections ending as simple trace represent inhibitory connections, as based on current knowledge of the chemical structure of these pathways. DA=Dopamine, DS=Dorsal striatum, LH=Lateral hypothalamic area, SNc=Substantia Nigra, pars compacta, SNr=Substantia Nigra, pars reticulata, VP=Ventral pallidum, VS=Ventral striatum.
